SYNTHESIS AND BIOLOGICAL ACTIVITY OF NITRIC OXIDE IN SMOOTH MUSCLE MITOCHONDRIA – BOOKS OF THE NATIONAL ACADEMY OF SCIENCES OF UKRAINE

Authors:

H.V. Danylovych
Palladin Institute of Biochemistry of the NAS of Ukraine, Kyiv
https://orcid.org/0000-0003-0571-4494
Scopus Author ID: 36099845500

Yu.V. Danylovych
Palladin Institute of Biochemistry of the NAS of Ukraine, Kyiv
https://orcid.org/0000-0002-3526-7085
Scopus Author ID: 6507778668
ResearcherID: KEJ-4225-2024

Reviewers:
R.S. Stoika
Corresponding member of NAS of Ukraine, Doctor of Science, Professor
Institute of Cell Biology, Lviv University
Head of Department (Regulation of Cell Proliferation and Apoptosis)
https://orcid.org/0000-0001-5719-2187
Scopus Author ID: 56144795900
SciProfiles: 1949844

O.Р. Matyshevska
Doctor of Science, Professor
Palladin Institute of Biochemistry of the NAS of Ukraine, Kyiv
Leading Researcher (department of Scientific and Technic Information)
https://orcid.org/0000-0003-0587-5124

А.О. Tykhomyrov
Doctor of Science, Senior Researcher
Palladin Institute of Biochemistry of the NAS of Ukraine, Kyiv
Head of Department (department of Enzyme Chemistry and Biochemistry)
https://orcid.org/0000-0003-2063-4636
Scopus Author ID: 23502292700

Affiliation:

Project: Scientific book

Year: 2024

Publisher: PH "Naukova Dumka"

Pages: 215

DOI:

https://doi.org/10.15407/978-966-00-1948-5

ISBN: 978-966-00-1948-5

Language: Ukrainian

How to Cite:

Abstract:

The monograph presents data from the current scientific literature and the results of our own comprehensive studies on the biochemical pathways of NO synthesis in the mitochondria of uterine smooth muscle cells. Special attention is paid to the molecular mechanisms of nitric oxide action as a possible endogenous specific regulator of Ca²⁺ concentration in myocytes, functioning of Ca²⁺ transport systems of mitochondria and bioenergetic processes in them. Experimental data on the effect of calix[4]arenes, exogenous non-toxic modulators of mitochondrial functional activity, on NO synthase capacity, bioenergetics, and Ca²⁺ homeostasis of organelles were analyzed. New answers are given to fundamental questions about the ways of smooth muscle relaxation.

Modern data on nitric oxide’s metabolism and physiological value have been thoroughly analyzed. Mainly, experimental material related to such issues as the synthesis of nitric oxide in the mitochondria of the smooth muscle of the uterus, nitric oxide regulation of Ca²⁺ homeostasis in myocytes and Ca²⁺ transport in the inner mitochondrial membrane, and the effect of nitric oxide on the electron transport chain has been set out. Considerable attention is paid to calix[4]arenes as a selective effectors on Ca²⁺ transport, NO synthesis, and energy processes in mitochondria.

For specialists in the field of biochemistry and biophysical chemistry, biochemical membranology and pharmacology, as well as for graduate students of the relevant specialties.

Keywords:

nitric oxide, NO-synthase, mitochondria, myometrium, Ca²⁺-homeostasis, plasmalemma potential, electron transport chain, inner mitochondrial membrane potential, calix[4]arenes

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CHAPTER 2

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CHAPTER 3

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Кosterin S.О., Кalchenko V.І., Veklich Т.О., Babich L.G., Shlykov S.G. Calixarenes as modulators of АТР-hydrilizing systems of smooth muscles. Кyiv: Naukova Dumka, 2019. 256 p.
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